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Eur J Obstet Gynecol Reprod Biol. 1995 Sep;62(1):49-52.

Management of low-grade CIN: follow-up or treatment?

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  • 1Department of Gynecology Y 4031, Rigshospitalet, University Hospital of Copenhagen, Denmark.

Abstract

OBJECTIVE:

To examine whether low-grade cervical dysplasia carries a higher risk of progression when associated with the cancer-related human papillomavirus types 16, 18, 31 or 33.

STUDY DESIGN:

Retrospective, with PCR-based HPV diagnosis on the original cervical biopsies from 71 patients with CIN I and II. CIN III developed in 34 lesions, and 37 showed complete regression during non-invasive follow-up.

RESULTS:

Progression occurred in 15/41 CIN I and in 19/30 CIN II lesions (P = 0.03). HPV DNA was detected in 43 specimens. CIN III developed in 25% of HPV-negative lesions, in 48% of HPV-positive CIN I lesions, and in 77% of HPV-positive CIN II lesions.

CONCLUSION:

Low-grade lesions are at higher risk of progression when associated with HPV types 16, 18, 31 or 33 (P = 0.002). HPV diagnosis can be useful in the triage of patients with low-grade CIN.

PMID:
7493708
[PubMed - indexed for MEDLINE]
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