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J Urol. 1996 Jan;155(1):105-9; discussion 109-10.

Detection of early bladder cancer by 5-aminolevulinic acid induced porphyrin fluorescence.

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  • 1Department of Urology, University of Munich, Germany.

Abstract

PURPOSE:

We determined whether the sensitivity of detecting dysplasia or early bladder cancer can be improved by 5-aminolevulinic acid induced porphyrin fluorescence.

MATERIALS AND METHODS:

A 3% 5-aminolevulinic acid solution was instilled intravesically before cystoscopy in 104 patients. The 5-aminolevulinic acid induced porphyrin fluorescence was excited by violet light from a krypton ion laser (wavelength 406.7 nm.).

RESULTS:

The sensitivity of the fluorescence cystoscopy (96.9%) was significantly (p < 0.0001) greater than that of white light cystoscopy (72.7%). There was no impact on specificity.

CONCLUSIONS:

Due to the high sensitivity of the procedure fluorescence guided biopsies are recommended instead of random biopsies.

PMID:
7490803
[PubMed - indexed for MEDLINE]
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