The main task of regional catastrophe medicine service in liquidation of medical consequences of emergency situations is the immediate adequate reaction which is aimed at minimizing the sanitary loss. This task can be effectively solved only on condition of permanent improvement of interaction between the managing and managed systems of public health and coordination of their actions with those of nonmedical services. An important role is played by the actualized (constantly renewed) data bases "Potentially Hazardous Objects", "Regional Infrastructure", "Medicosanitary Means", etc., which help simulate various emergency situations with due consideration for the season, time of the day, and socioeconomic features of a region in order to create variants of effective work of all services engaged in the liquidation of medical consequences.