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Neurosci Lett. 1995 Jul 14;194(1-2):49-52.

Behavioural deficits in adult rats following long-term adrenalectomy.

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  • 1Department of Clinical Neuroscience and Family Medicine, Karolinska Institute, Huddinge Hospital, Sweden.


Long-term adrenalectomy results in loss of neurones in the hippocampal formation of the adult rat. The effects of long-term adrenalectomy on spatial learning and exploratory behaviour in adrenalectomized (ADX), adrenalectomized normal weight gain (ADXNW), sham operated and naive control male Sprague-Dawley rats were investigated in this study. The ADX rats had significantly longer latencies in the Morris maze task compared to the other groups. In the open-field situation, as a novel finding, the ADX rats showed significantly lower rearing scores compared to other groups. These data indicate that long-term adrenalectomy causes impairment in spatial learning and explorative behaviour in the rat.

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