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1: Nature. 1995 Oct 26;377(6551):744-7.Click here to read Links
Erratum in:
Nature 1996 Mar 28;380(6572):366.

Behavioural and cardiovascular effects of disrupting the angiotensin II type-2 receptor in mice.

Hein L, Barsh GS, Pratt RE, Dzau VJ, Kobilka BK.

Falk Cardiovascular Research Center, Stanford University, California 94305, USA.

Angiotensin II, a potent regulator of blood pressure and of water and electrolyte balance, binds to two different G-protein-coupled receptors. The type-1 receptor (AT1) mediates the vasopressive and aldosterone-secreting effects of angiotensin II, but the function of the type-2 receptor (AT2) is unknown, although it is expressed in both adult and embryonic life. To address this question, we have generated mice lacking the gene encoding the AT2 receptor. Mutant mice develop normally, but have an impaired drinking response to water deprivation as well as a reduction in spontaneous movements. Their baseline blood pressure is normal, but they show an increased vasopressor response to injection of angiotensin II. Thus, although the AT2 receptor is not required for embryonic development, it plays a role in the central nervous system and cardiovascular functions that are mediated by the renin-angiotensin system.

PMID: 7477266 [PubMed - indexed for MEDLINE]