Format

Send to:

Choose Destination
See comment in PubMed Commons below
J Theor Biol. 1995 Sep 7;176(1):115-24.

Michaelis-Menten mechanism reconsidered: implications of fractal kinetics.

Author information

  • 1Department of Microbiology and Immunology, University of Michigan, Ann Arbor 14809-0620, USA.

Abstract

The Michaelis-Menten formalism assumes that the elementary steps of an enzymatic mechanism follow traditional mass-action kinetics. Recent evidence has shown that elementary bimolecular reactions under dimensionally-restricted conditions, such as those that might occur in vivo when reactions are confined to two-dimensional membranes and one-dimensional channels, do not follow traditional mass-action kinetics, but fractal kinetics. A Michaelis-Menten-like reaction operating under conditions of dimensional restriction is shown to exhibit new types of synergism and noninteger kinetic orders. These properties are likely to have an important influence on the behavior of intact biochemical systems, which is largely dependent upon the kinetic orders of the constituent biochemical reactions.

PMID:
7475096
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk