A trial of propranolol for the treatment of vasomotor symptoms was conducted among 37 menopausal women in a double-blind, placebo-controlled, crossover fashion. When compared with placebo, propranolol had a statistically significant effect on the reduction of both the frequency and severity of vasomotor symptoms (P less than 0.01). In selected patients, propranolol may be an alternative to the treatment of vasomotor symptoms with exogenous estrogens.