Boll Soc Ital Biol Sper. 1980 Dec 15;56(23):2486-91.

[Renal and hepatic toxicity studies in mice treated with sodium saccharin: breaks in single-stranded DNA].

[Article in Italian]

Abstract

The renal and hepatic effects of in vivo treatment with saccharin have been determined as increased DNA elutability on filter. A direct dose-damage relationship was not observed in the kidney and in the liver DNA of treated mice. Doses of 50, 100 and 200 mg/Kg seem to induce in almost all the experiments the same level of single-stranded breaks. The DNA elutability is increased in the range 130-210 % if compared with controls.

PMID:: 7470290; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances

Publication Types

English Abstract

MeSH Terms

Substances

LinkOut - more resources

Molecular Biology Databases

SACCHARIN - HSDB

Supplemental Content

Related citations

NTP Toxicology and Carcinogenesis Studies of Coumarin (CAS No. 91-64-5) in F344/N Rats and B6C3F1 Mice (Gavage Studies). [Natl Toxicol Program Tech Rep Ser. 1993]
NTP Toxicology and Carcinogenesis Studies of Coumarin (CAS No. 91-64-5) in F344/N Rats and B6C3F1 Mice (Gavage Studies).
National Toxicology Program. Natl Toxicol Program Tech Rep Ser. 1993 Sep; 422:1-340.
Genotoxicity of ochratoxin A in mice: DNA single-strand break evaluation in spleen, liver and kidney. [Toxicol Lett. 1985]
Genotoxicity of ochratoxin A in mice: DNA single-strand break evaluation in spleen, liver and kidney.
Creppy EE, Kane A, Dirheimer G, Lafarge-Frayssinet C, Mousset S, Frayssinet C. Toxicol Lett. 1985 Oct; 28(1):29-35.
DNA single-strand breaks in kidneys of Syrian hamsters treated with steroidal estrogens: hormone-induced free radical damage preceding renal malignancy. [Carcinogenesis. 1994]
DNA single-strand breaks in kidneys of Syrian hamsters treated with steroidal estrogens: hormone-induced free radical damage preceding renal malignancy.
Han X, Liehr JG. Carcinogenesis. 1994 May; 15(5):997-1000.
NTP Toxicology and Carcinogenesis Studies of 1,4-Dichlorobenzene (CAS No. 106-46-7) in F344/N Rats and B6C3F1 Mice (Gavage Studies). [Natl Toxicol Program Tech Rep Ser. 1987]
NTP Toxicology and Carcinogenesis Studies of 1,4-Dichlorobenzene (CAS No. 106-46-7) in F344/N Rats and B6C3F1 Mice (Gavage Studies).
National Toxicology Program. Natl Toxicol Program Tech Rep Ser. 1987 Jan; 319:1-198.
The male rat carcinogens limonene and sodium saccharin are not mutagenic to male Big Blue rats. [Mutagenesis. 2001]
The male rat carcinogens limonene and sodium saccharin are not mutagenic to male Big Blue rats.
Turner SD, Tinwell H, Piegorsch W, Schmezer P, Ashby J. Mutagenesis. 2001 Jul; 16(4):329-32.

See reviews... See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.

Recent activity

Clear Turn Off Turn On

[Renal and hepatic toxicity studies in mice treated with sodium saccharin: break...
[Renal and hepatic toxicity studies in mice treated with sodium saccharin: breaks in single-stranded DNA].
Boll Soc Ital Biol Sper. 1980 Dec 15 ;56(23):2486-91.

PubMed
Markov models in medical decision making: a practical guide.
Markov models in medical decision making: a practical guide.
Med Decis Making. 1993 Oct-Dec ;13(4):322-38.

PubMed
Neonatal respiratory morbidity and mode of delivery at term: influence of timing...
Neonatal respiratory morbidity and mode of delivery at term: influence of timing of elective caesarean section.
Br J Obstet Gynaecol. 1995 Feb ;102(2):101-6.

PubMed
Prolonged delirium tremens requiring massive doses of medication.
Prolonged delirium tremens requiring massive doses of medication.
J Am Board Fam Pract. 1993 Sep-Oct ;6(5):502-4.

PubMed
Fibulin binds to itself and to the carboxyl-terminal heparin-binding region of f...
Fibulin binds to itself and to the carboxyl-terminal heparin-binding region of fibronectin.
J Biol Chem. 1992 Oct 5 ;267(28):20120-5.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Display Settings:

Send to:

[Renal and hepatic toxicity studies in mice treated with sodium saccharin: breaks in single-stranded DNA].

Abstract

Publication Types, MeSH Terms, Substances

Publication Types

MeSH Terms

Substances

LinkOut - more resources

Molecular Biology Databases

Supplemental Content

Related citations

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information