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    Ann Intern Med. 1980 Jul;93(1):53-4.

    Primidone in the treatment of the long QT syndrome: QT shortening and ventricular arrhythmia suppression.

    DeSilvey DL, Moss AJ.

    We studied a family with the long QT syndrome. The initial case was in a patient who presented with seizures, ventricular fibrillation, and syncope. After a trial of conventional modalities of treatment including left stellate ganglionectomy, primidone (Mysoline) therapy was initiated. This drug has been successful in suppressing ventricular arrhythmias and shortening the QT interval over a 2-year follow-up period. Two additional family members with QT prolongation have been treated with primidone. During an 8-month follow-up, electrocardiographic and Holter recordings showed shortening of the QT interval.

    PMID: 7396315 [PubMed - indexed for MEDLINE]

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    Patient drug information

    • Phenobarbital (Luminal® Sodium)

      Phenobarbital, a barbiturate, is used to control epilepsy (seizures) and as a sedative to relieve anxiety. It is also used for short-term treatment of insomnia to help you fall asleep.

    • Primidone (Mysoline®)

      Primidone is used alone or with other medications to control certain types of seizures. Primidone is in a class of medications called anticonvulsants. It works by decreasing abnormal electrical activity in the brain.

    • Source: AHFS Consumer Medication Information

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