Eye examinations performed on the survivors of the Framingham Heart Study Cohort showed a prevalence of senile lens changes ranging from 42% at ages 52 to 64 years to 91% at ages 75 to 85 years. The prevalence of senile macular changes increased from 35% at 52 to 64 years to 50% at 75 to 85 years. Persons affected with either condition usually had bilateral involvement. No association between the two conditions was shown.