N Engl J Med. 1980 May 22;302(21):1163-8.

An inherited abnormality of neutrophil adhesion. Its genetic transmission and its association with a missing protein.

Crowley CA, Curnutte JT, Rosin RE, André-Schwartz J, Gallin JI, Klempner M, Snyderman R, Southwick FS, Stossel TP, Babior BM.

Abstract

Neutrophils from a five-year-old boy with recurrent bacterial infections failed to spread on surfaces, leading to a severe defect in chemotaxis and a mild impairment in phagocytosis. Failure to spread was also seen in a fraction of the neutrophils from the patient's mother and sister, but cells from his father and brother were normal. Gel electrophoresis revealed that a protein with a molecular weight of 110,000 daltons (designated gp 110) present in the particulate fraction of normal neutrophils was absent from the patient's cells, and that its levels were below normal in cells from his mother and sister but normal in neutrophils from his father and brother. These findings suggest that gp 110 is necessary for the spreading of neutrophils onto surfaces, that the functional abnormality in the patient's cells is caused by its absence, and that deficiency of gp 110 is an X-linked congenital disease.

PMID:: 7366657; [PubMed - indexed for MEDLINE]

LinkOut - more resources

Full Text Sources

Other Literature Sources

COS Scholar Universe

Supplemental Content

Save items

Related citations in PubMed

An abnormality of neutrophil adhesion: autosomal recessive inheritance associated with missing neutrophil glycoproteins. [Pediatrics. 1984]
An abnormality of neutrophil adhesion: autosomal recessive inheritance associated with missing neutrophil glycoproteins.
Kobayashi K, Fujita K, Okino F, Kajii T. Pediatrics. 1984 May; 73(5):606-10.
Abnormal adherence-related functions of neutrophils, monocytes, and Epstein-Barr virus-transformed B cells in a patient with C3bi receptor deficiency. [Blood. 1985]
Abnormal adherence-related functions of neutrophils, monocytes, and Epstein-Barr virus-transformed B cells in a patient with C3bi receptor deficiency.
Buescher ES, Gaither T, Nath J, Gallin JI. Blood. 1985 Jun; 65(6):1382-90.
An inherited defect of neutrophil motility and microfilamentous cytoskeleton associated with abnormalities in 47-Kd and 89-Kd proteins. [Blood. 1991]
An inherited defect of neutrophil motility and microfilamentous cytoskeleton associated with abnormalities in 47-Kd and 89-Kd proteins.
Coates TD, Torkildson JC, Torres M, Church JA, Howard TH. Blood. 1991 Sep 1; 78(5):1338-46.
Review Neutrophil function tests. [Baillieres Clin Haematol. 1990]
Review Neutrophil function tests.
Haynes AP, Fletcher J. Baillieres Clin Haematol. 1990 Oct; 3(4):871-87.
Review Disorders of stimulus-response coupling in neutrophils. [Clin Lab Med. 1983]
Review Disorders of stimulus-response coupling in neutrophils.
Smolen JE, Boxer LA. Clin Lab Med. 1983 Dec; 3(4):779-800.

See reviews... See all...

Cited by 38 PubMed Central articles

Fas-mediated neutrophil apoptosis is accelerated by Bid, Bak, and Bax and inhibited by Bcl-2 and Mcl-1. [Proc Natl Acad Sci U S A. 2011]
Fas-mediated neutrophil apoptosis is accelerated by Bid, Bak, and Bax and inhibited by Bcl-2 and Mcl-1.
Croker BA, O'Donnell JA, Nowell CJ, Metcalf D, Dewson G, Campbell KJ, Rogers KL, Hu Y, Smyth GK, Zhang JG, et al. Proc Natl Acad Sci U S A. 2011 Aug 9; 108(32):13135-40. Epub 2011 Jul 18.
Mary Allen Engle Award: The glue of life--a career retrospective. [Trans Am Clin Climatol Assoc. ...]
Mary Allen Engle Award: The glue of life--a career retrospective.
Todd RF 3rd. Trans Am Clin Climatol Assoc. 2011; 122:138-49.
Review The vessel wall and its interactions. [Blood. 2008]
Review The vessel wall and its interactions.
Wagner DD, Frenette PS. Blood. 2008 Jun 1; 111(11):5271-81.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Gene (OMIM)
Gene records associated with Online Mendelian Inheritance in Man (OMIM) records that cite the current articles in their reference lists.
Nucleotide (Weighted)
Nucleotide records associated with the current articles through the Gene database. These are the related sequences on the Gene record that are added manually by NCBI.
OMIM (calculated)
Online Mendelian Inheritance in Man (OMIM) records that include the current articles as references in the light bulb links within or in the citations at the end of the OMIM record. The references available through the light bulb link are collected using the PubMed related articles algorithm to identify records with similar terminology to the OMIM record.
OMIM (cited)
Online Mendelian Inheritance in Man (OMIM) records that include the current articles as reference cited at the end of the OMIM record.
Protein (Weighted)
Protein records associated with the current articles through related Gene database records. These are the related sequences on the Gene record that are added manually by NCBI.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

An inherited abnormality of neutrophil adhesion. Its genetic transmission and it...
An inherited abnormality of neutrophil adhesion. Its genetic transmission and its association with a missing protein.
N Engl J Med. 1980 May 22 ;302(21):1163-8.

PubMed
A system for quantitative evaluation of left ventricular function with two-dimen...
A system for quantitative evaluation of left ventricular function with two-dimensional ultrasonography.
Med Instrum. 1980 Mar-Apr ;14(2):111-6.

PubMed
An epidemic of suicide among physicians on probation.
An epidemic of suicide among physicians on probation.
JAMA. 1980 May 16 ;243(19):1915-7.

PubMed
Basal cell carcinoma of the nipple.
Basal cell carcinoma of the nipple.
Arch Dermatol. 1978 Dec ;114(12):1845.

PubMed
The misdiagnosis of black patients with manic depressive illness.
The misdiagnosis of black patients with manic depressive illness.
J Natl Med Assoc. 1980 Feb ;72(2):141-5.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to:

An inherited abnormality of neutrophil adhesion. Its genetic transmission and its association with a missing protein.

Abstract

Publication Types, MeSH Terms, Substances

Publication Types

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Other Literature Sources

Supplemental Content

Save items

Related citations in PubMed

Cited by 38 PubMed Central articles

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information