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Psoriasis, methotrexate, and oligospermia.
A young man with severe psoriasis was treated intermittently with methotrexate. On two different occasions, severe oligospermia documented by serial seminal fluid analyses was present coincident with methotrexate administration. Discontinuation of methotrexate resulted in normal sperm concentration. Measurements of serum gonadotrophin and testosterone levels were normal during and after methotrexate treatment. It is concluded that methotrexate administration may result in severe oligospermia and that these inhibiting effects on spermatogenesis are reversible.
PMID: 7356357 [PubMed - indexed for MEDLINE]
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Cited by 3 PubMed Central articles
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Anti-inflammatory and immunosuppressive drugs and reproduction.
Østensen M, Khamashta M, Lockshin M, Parke A, Brucato A, Carp H, Doria A, Rai R, Meroni P, Cetin I, et al.
Arthritis Res Ther. 2006; 8(3):209. Epub 2006 May 11.
[Arthritis Res Ther. 2006]
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Effect of methotrexate on male fertility.
French AE, Koren G, Motherisk Team.
Can Fam Physician. 2003 May; 49:577-8.
[Can Fam Physician. 2003]
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Drugs and sperm.
Drife JO.
Br Med J (Clin Res Ed). 1982 Mar 20; 284(6319):844-5.
[Br Med J (Clin Res Ed). 1982]
Patient Drug Information
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Methotrexate (Rheumatrex® , Trexall® )
Methotrexate is used to treat severe psoriasis (a skin disease in which red, scaly patches form on some areas of the body) that cannot be controlled by other treatments. Methotrexate is also used along with rest, physica...