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Acta Biol Med Ger. 1981;40(9):1139-43.

Action of rat liver cathepsin L on glucagon.

Abstract

The proteolytic specificity of cathepsin L on glucagon was determined. Major cleavages are found between Thr7 and Ser8, Asp15 and Ser16, and between Met27 and Asn28. The bonds Ser11-Lys12, Val23-Gln24, and Gln24-Trp25 are hydrolyzed to a relatively low extent only. Whereas cathepsin B hydroxyzes glucagon at the C-terminus by a peptidyldipeptidase mechanism, cathepsin L cleaves the same substrate clearly as endopeptidase.

PMID:
7340337
[PubMed - indexed for MEDLINE]
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