[Effectiveness of different alpha-tocopherol derivatives in preventing experimental muscular dystrophy in chickens]

Vopr Med Khim. 1981 Nov-Dec;27(6):760-3.
[Article in Russian]

Abstract

Activity of vitamin E and its derivatives--alpha-tocopheryl quinone, its short chain analogue and alpha-tocopheryl acetate also containing short chain molecule were studied during chicken experimental muscular dystrophy. alpha-Tocopheryl quinone containing short chain molecule proved to be the most active substance; similarly to vitamin E the preparation increased the erythrocyte resistance to osmotic haemolysis, distinctly increased the content of ubiquinone and decreased concentration of ubichromenol in the chicken liver tissue as compared with E-deficient animals. At the same time, the content of ubiquinone was unaltered in skeletal muscles. The data obtained suggest that vitamin E could be effectively substituted by its derivatives for prevention an treatment of muscular dystrophy.

Publication types

  • Comparative Study

MeSH terms

  • Animals
  • Chickens*
  • Drug Evaluation, Preclinical
  • Muscular Dystrophy, Animal / etiology
  • Muscular Dystrophy, Animal / metabolism
  • Muscular Dystrophy, Animal / prevention & control*
  • Tocopherols
  • Vitamin E / analogs & derivatives*
  • Vitamin E / metabolism
  • Vitamin E / therapeutic use
  • Vitamin E Deficiency / complications
  • alpha-Tocopherol* / analogs & derivatives*

Substances

  • Vitamin E
  • tocopherylquinone
  • alpha-Tocopherol
  • Tocopherols