Eur J Pharmacol. 1981 Aug 27;74(1):73-81.

In vivo modulation of the number of muscarinic receptors in rat brain by cholinergic ligands.

Ben-Barak J, Gazit H, Silman I, Dudai Y.

Abstract

Administration of the muscarinic agonist oxotremorine led to a decrease in the number of muscarinic receptors, as determined by specific binding of [3H]quinuclidinyl benzilate ([3H]QNB), in several rat brain regions both during development and at maturity. In contrast, administration of the muscarinic antagonist scopolamine led to an increase in the number of [3H]QNB-binding sites in various brain regions. Scopolamine also prevented the decrease in the number of [3H]QNB-binding sites induced by administration of an organophosphorus drug. The results are compatible with the hypothesis that the number of brain muscarinic receptors, or at least of a sub-class of them, is regulated by their transmitter.

PMID:: 7318895; [PubMed - indexed for MEDLINE]

LinkOut - more resources

Molecular Biology Databases

Supplemental Content

Save items

Related citations in PubMed

In vitro and in vivo modulation of cholinergic muscarinic receptors in rat lymphocytes and brain by cholinergic agents. [Int J Immunopharmacol. 1990]
In vitro and in vivo modulation of cholinergic muscarinic receptors in rat lymphocytes and brain by cholinergic agents.
Costa LG, Kaylor G, Murphy SD. Int J Immunopharmacol. 1990; 12(1):67-75.
Characterization of [3H]pirenzepine binding to muscarinic cholinergic receptors solubilized from rat brain. [J Pharmacol Exp Ther. 1985]
Characterization of [3H]pirenzepine binding to muscarinic cholinergic receptors solubilized from rat brain.
Luthin GR, Wolfe BB. J Pharmacol Exp Ther. 1985 Jul; 234(1):37-44.
Differential inhibition of [3H]-oxotremorine-M and [3H]-quinuclinidyl benzilate binding to muscarinic receptors in rat brain membranes with acetylcholinesterase inhibitors. [Naunyn Schmiedebergs Arch Phar...]
Differential inhibition of [3H]-oxotremorine-M and [3H]-quinuclinidyl benzilate binding to muscarinic receptors in rat brain membranes with acetylcholinesterase inhibitors.
Lockhart B, Closier M, Howard K, Steward C, Lestage P. Naunyn Schmiedebergs Arch Pharmacol. 2001 Apr; 363(4):429-38.
Review Biochemical indentification of the mammalian muscarinic cholinergic receptor. [Fed Proc. 1975]
Review Biochemical indentification of the mammalian muscarinic cholinergic receptor.
Snyder SH, Chang KJ, Kuhar MJ, Yamamura HI. Fed Proc. 1975 Sep; 34(10):1915-21.
Review Neurotransmitter receptors as targets for pesticides. [J Environ Sci Health B. 1983]
Review Neurotransmitter receptors as targets for pesticides.
Eldefrawi ME, Eldefrawi AT. J Environ Sci Health B. 1983; 18(1):65-88.

See reviews... See all...

Cited by 1 PubMed Central article

The binding properties of the muscarinic receptors of the cynomolgus monkey ciliary body and the response to the induction of agonist subsensitivity. [Br J Pharmacol. 1982]
The binding properties of the muscarinic receptors of the cynomolgus monkey ciliary body and the response to the induction of agonist subsensitivity.
Bárány E, Berrie CP, Birdsall NJ, Burgen AS, Hulme EC. Br J Pharmacol. 1982 Dec; 77(4):731-9.

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound
PubChem chemical compound records that cite the current articles. These references are taken from those provided on submitted PubChem chemical substance records. Multiple substance records may contribute to the PubChem compound record.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Substance
PubChem chemical substance records that cite the current articles. These references are taken from those provided on submitted PubChem chemical substance records.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

In vivo modulation of the number of muscarinic receptors in rat brain by choline...
In vivo modulation of the number of muscarinic receptors in rat brain by cholinergic ligands.
Eur J Pharmacol. 1981 Aug 27 ;74(1):73-81.

PubMed
Volvulus of the splenic flexure: report of a case and review of the literature.
Volvulus of the splenic flexure: report of a case and review of the literature.
Dis Colon Rectum. 1981 Nov-Dec ;24(8):630-2.

PubMed
Novel bacterial structures in human blood. II. Bacterial variants as etiologic a...
Novel bacterial structures in human blood. II. Bacterial variants as etiologic agents in idiopathic hematuria.
J Urol. 1978 Dec ;120(6):708-11.

PubMed
Culture and psychiatry.
Culture and psychiatry.
Can J Psychiatry. 1981 Dec ;26(8):522-9.

PubMed
Nucleotide sequence of the F protein coding region of bacteriophage phiX174 and ...
Nucleotide sequence of the F protein coding region of bacteriophage phiX174 and the amino acid sequence of its product.
J Mol Biol. 1978 Oct 25 ;125(2):247-54.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to:

In vivo modulation of the number of muscarinic receptors in rat brain by cholinergic ligands.

Abstract

Publication Types, MeSH Terms, Substances

Publication Types

MeSH Terms

Substances

LinkOut - more resources

Molecular Biology Databases

Supplemental Content

Save items

Related citations in PubMed

Cited by 1 PubMed Central article

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information