Cancer. 1981 Dec 15;48(12):2742-5.

A comparison of cancer risk in Crohn's disease and ulcerative colitis.

Greenstein AJ, Sachar DB, Smith H, Janowitz HD, Aufses AH Jr.

Abstract

The authors estimated cancer risk among 589 patients hospitalized with Crohn's disease between 1960-1976 by calculating the ratios of observed number of cancers (O) in our hospital sample to the expected number of cancers (E) based on the age- and sex-specific cancer rates of a standard population. The authors then compared these O/E ratios with the O/E ratios similarly calculated among 267 patients hospitalized with ulcerative colitis. The risk of colorectal cancer was significantly increased in Crohn's disease (O/E = 6.9, P less than 0.001). This increase was similar in magnitude to that found in left-sided ulcerative colitis (O/E = 8.6, P less than 0.001) but was much less than that found in universal ulcerative colitis (O/E = 26.5, P less than 0.001). The incidence of small bowel cancer was greatly increased in the combined group of regional enteritis and ileocolitis (O/E = 85.8, P less than 0.001), and even more so in the regional enteritis group alone (O/E = 114.5, P less than 0.001). The incidence of extraintestinal cancer did not increase in any of the patient groups.

PMID:: 7306930; [PubMed - indexed for MEDLINE]

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A comparison of cancer risk in Crohn's disease and ulcerative colitis.

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Medical

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Cited by 18 PubMed Central articles

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