Your browser version may not work well with NCBI's Web applications. More information here...
1: Ann Intern Med. 1981 Nov;95(5):588-90.Links

Allopurinol hepatotoxicity. Report of two cases and review of the literature.

Al-Kawas FH, Seeff LB, Berendson RA, Zimmerman HJ, Ishak KG.

Allopurinol hepatotoxicity occurred in two patients. Data from the literature suggest that allopurinol can occasionally cause liver injury, particularly in persons receiving diuretic drugs or with compromised renal function. Clinical and laboratory findings are consistent with hepatocellular injury mediated by a hypersensitivity reaction. Most patients recover when the drug is withdrawn; the possible benefits of corticosteroid treatment remain to be established.

PMID: 7294548 [PubMed - indexed for MEDLINE]

Patient Drug Information

  • Allopurinol (Aloprim® , Zyloprim® )

    Allopurinol is used to treat gout, high levels of uric acid in the body caused by certain cancer medications, and kidney stones. Allopurinol is in a class of medications called xanthine oxidase inhibitors. It works by re...

  • Source: AHFS Consumer Medication Information