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Long-standing asymptomatic primary sclerosing cholangitis: report of three cases.
Three patients, two males and one female, with asymptomatic primary sclerosing cholangitis (PSC) are described. The diagnosis was made in each case by endoscopic retrograde cholangiography after investigation of persistent elevation of the serum alkaline phosphatase. All three have remained completely well without any medical or surgical treatment for 3, 7, and 15 years, respectively, despite extensive involvement of the biliary tree. Follow-up liver biopsies in two have shown no histological evidence of progression to secondary biliary cirrhosis. PSC may occur more frequently and may follow a less severe clinical course than previously recognized.
PMID: 7285744 [PubMed - indexed for MEDLINE]
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Cited by 4 PubMed Central articles
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Natural history and prognostic factors in 305 Swedish patients with primary sclerosing cholangitis.
Broomé U, Olsson R, Lööf L, Bodemar G, Hultcrantz R, Danielsson A, Prytz H, Sandberg-Gertzén H, Wallerstedt S, Lindberg G.
Gut. 1996 Apr; 38(4):610-5.
[Gut. 1996]
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A case of longstanding primary sclerosing cholangitis.
Goudie BM, Birnie GG, Watkinson G, MacSween RN.
J Clin Pathol. 1983 Nov; 36(11):1298-301.
[J Clin Pathol. 1983]
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Macroscopically-localized hepatic lesions in sclerosing cholangitis.
Touquet VL.
J R Soc Med. 1983 Sep; 76(9):789-90.
[J R Soc Med. 1983]
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