In summary, there are various factors which play an important prognostic role in the final visual acuity of patients with active histoplasma maculopathy. The factors over which we have no control is the location of the neovascular membrane in this maculopathy. The factors over which we do have control are how and when to treat it. We feel that laser photocoagulation is an effective method of treatment. It has been possible to obliterate the NVM as close as 200 micrometers from the foveola, thus preventing the development of subfoveal NVMs which have such a poor visual prognosis. The most important factor is the early treatment with laser photocoagulation. If we could treat all patients within 4 weeks of initial visual symptoms (group A), we might be able to eliminate a large number of patients (group C) who have a much poorer visual prognosis. Serial postoperative fluorescein studies are necessary to detect recurrent neovascular membranes which require further treatment.