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J R Soc Med. 1980 Oct;73(10):727-30.

Comparison of the effects of atropine and glycopyrrolate on various end-organs.

Abstract

Atropine and glycopyrrolate (glycopyrronium bromide), a quaternary ammonium drug, were evaluated in volunteers following intramuscular administration with respect to effects on various end-organs with cholinergic innervation. Glycopyrrolate appears to be five to six times more potent than atropine in its antisialogogue effect and also exhibits a selective, though prolonged, effect on salivary secretion and sweat gland activity. It has minimal cardiovascular, ocular and central nervous system effects.

PMID:
7241426
[PubMed - indexed for MEDLINE]
PMCID:
PMC1438092
Free PMC Article
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