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Sequence and organization of the human mitochondrial genome.
Anderson S,
Bankier AT,
Barrell BG,
de Bruijn MH,
Coulson AR,
Drouin J,
Eperon IC,
Nierlich DP,
Roe BA,
Sanger F,
Schreier PH,
Smith AJ,
Staden R,
Young IG.
The complete sequence of the 16,569-base pair human mitochondrial genome is presented. The genes for the 12S and 16S rRNAs, 22 tRNAs, cytochrome c oxidase subunits I, II and III, ATPase subunit 6, cytochrome b and eight other predicted protein coding genes have been located. The sequence shows extreme economy in that the genes have none or only a few noncoding bases between them, and in many cases the termination codons are not coded in the DNA but are created post-transcriptionally by polyadenylation of the mRNAs.
PMID: 7219534 [PubMed - indexed for MEDLINE]
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Cited by over 100 PubMed Central articles
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How do human cells react to the absence of mitochondrial DNA?
Mineri R, Pavelka N, Fernandez-Vizarra E, Ricciardi-Castagnoli P, Zeviani M, Tiranti V.
PLoS One. 2009 May 28; 4(5):e5713. Epub 2009 May 28.
[PLoS One. 2009]
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Mitochondrial DNA Mutations in etiopathogenesis of male infertility.
Shamsi MB, Kumar R, Bhatt A, Bamezai RN, Kumar R, Gupta NP, Das TK, Dada R.
Indian J Urol. 2008 Apr; 24(2):150-4.
[Indian J Urol. 2008]
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Single-molecule LATE-PCR analysis of human mitochondrial genomic sequence variations.
Osborne A, Reis AH, Bach L, Wangh LJ.
PLoS One. 2009 May 20; 4(5):e5636. Epub 2009 May 20.
[PLoS One. 2009]
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