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    Science. 1981 Apr 17;212(4492):340-1.

    Astatine-211--tellurium radiocolloid cures experimental malignant ascites.

    Abstract

    An investigation of the efficacy of astatine-211--tellurium colloid for the treatment of experimental malignant ascites in mice reveals that this alpha-emitting radiocolloid can be curative without causing undue toxicity to normal tissue. By comparison, negatron-emitting phosphorus-32 as colloidal chromic phosphate had no antineoplastic activity. The most compelling explanation for this striking difference is the dense ionization and short range of action associated with alpha-emission. These results have important implications for the development and use of alpha-emitters as radiocolloid therapy for the treatment of human tumors.

    PMID:
    7209534
    [PubMed - indexed for MEDLINE]

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