Science. 1982 Apr 23;216(4544):436-7.

Heroin "overdose" death: contribution of drug-associated environmental cues.

Siegel S, Hinson RE, Krank MD, McCully J.

Abstract

A model of "overdose" deaths among heroin addicts is proposed which emphasizes recent findings concerning the contribution of drug-associated environmental cues to drug tolerance. Results of animal experiments performed to evaluate this model suggest that conditioned drug-anticipatory responses, in addition to pharmacological factors, affect heroin-induced mortality.

PMID:: 7200260; [PubMed - indexed for MEDLINE]

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Heroin "overdose" death: contribution of drug-associated environmental cues.

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