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Fertil Steril. 1982 Mar;37(3):379-83.

Chromosome abnormalities in 150 couples with multiple spontaneous abortions.


One hundred fifty consecutive couples with recurrent abortions with or without fetal deaths, malformations, or healthy infants were evaluated cytogenetically with a G-band method. Seven couples (4.7%) showed a chromosome aberration in one partner (5 translocations, 1 inversion, and 1 gonosomal mosaicism). Of the couples with a pure abortion history, 2.9% had a chromosomal abnormality. A high incidence of chromosomal rearrangements in the groups of couples with abortions plus fetal deaths or malformations was found. In contrast to other reports, a high incidence of cytogenetic abnormalities was also found in couples with abortions and healthy infants. Chromosome analysis is advocated as a primary tool in the evaluation of couples with repetitive fetal wastage.

[PubMed - indexed for MEDLINE]
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