Display Settings:


Send to:

Choose Destination
See comment in PubMed Commons below
Arzneimittelforschung. 1980;30(9):1535-8.

Chronopharmacokinetics of pentazocine in the beagle dog.


Drug disposition of pentazocine was studied in the beagle dog upon i.v. administration of 30 mg in a crossover design with the variable being the time of administration. The pharmacokinetic parameters for the volume of distribution at steady state (V dss) and during the beta-phase (V d beta) and the biological half-life (t 1/2 beta) are statistically significant increased during the night, documenting circadian rhythm for the disposition of pentazocine. The total clearance (Cltot), however, remains unchanged.

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Loading ...
    Write to the Help Desk