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Chronic vitamin A intoxication in infants fed chicken liver.
Twin female infants were fed 120 gm of chicken liver homogenate daily for four months. They developed irritability, vomiting, and bulging anterior fontanelles. Computed tomograms of the brain revealed enlarged ventricles in both infants and dilated subarachnoid spaces in one. Plasma vitamin A concentrations were elevated. After all sources of vitamin A intake were stopped, the infants recovered without sequelae. The chicken liver homogenate contained 36,000 IU of vitamin A per 120 gm. Since infants often receive 4,000 units of vitamin A daily from fortified milk and vitamin supplements, they probably cannot be fed 60 gm of chicken liver safely more often than once weekly.
PMID: 7189278 [PubMed - indexed for MEDLINE]
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Cited by 3 PubMed Central articles
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Safety of one 52-mumol (50,000 IU) oral dose of vitamin A administered to neonates.
Agoestina T, Humphrey JH, Taylor GA, Usman A, Subardja D, Hidayat S, Nurachim M, Wu L, Friedman DS, West KP Jr.
Bull World Health Organ. 1994; 72(6):859-68.
[Bull World Health Organ. 1994]
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Intoxication from vitamin A in an asthmatic child.
Patel P, Hanning RM, Atkinson SA, Dent PB, Dolovich J.
CMAJ. 1988 Oct 15; 139(8):755-6.
[CMAJ. 1988]
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ReviewMegavitamin and megamineral therapy in childhood. Nutrition Committee, Canadian Paediatric Society.
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CMAJ. 1990 Nov 15; 143(10):1009-13.
[CMAJ. 1990]