Simplified technique to produce toxemia in the rat: considerations on cause of toxemia

Clin Exp Hypertens B. 1982;1(1):93-103. doi: 10.3109/10641958209037183.

Abstract

Under ether anesthesia a silver clip was placed around the abdominal aorta of pregnant rats, thus reducing the uterine blood flow by 35-45%. This resulted in a toxemia-like syndrome comparable to the one previously produced in other animal species. Consideration is given to the hypothesis that, in a similar way, compression of the abdominal aorta by the pregnant uterus in humans produces uterine ischemia leading to toxemia.

MeSH terms

  • Animals
  • Aorta, Abdominal / surgery
  • Blood Pressure
  • Constriction
  • Endothelium / pathology
  • Endothelium / ultrastructure
  • Female
  • Infarction / etiology
  • Methods
  • Muridae / physiology*
  • Placenta / blood supply
  • Pre-Eclampsia / etiology*
  • Pre-Eclampsia / physiopathology
  • Pregnancy
  • Pregnancy Complications, Cardiovascular / etiology*
  • Pregnancy Complications, Cardiovascular / physiopathology
  • Proteinuria / physiopathology