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Med Pediatr Oncol. 1982;10 Suppl 1:5-26.

Cellular aspects of the action of cytosine arabinoside.

Abstract

The cellular effects of Ara-C are reviewed including its S-phase sensitivity, its proliferative-dependent cytotoxicity and progression delay effects which result in unbalance growth. Both direct and indirect cytotoxic mechanisms are discussed. The impact of such cellular information on the scheduling of Ara-C is presented with regard to normal and tumor cell population cytotoxicity. Based on these data a therapeutic rationale is presented.

PMID:
7162467
[PubMed - indexed for MEDLINE]
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