Science. 1978 Dec 1;202(4371):988-91.

beta-Endorphin is associated with overeating in genetically obese mice (ob/ob) and rats (fa/fa).

Margules DL, Moisset B, Lewis MJ, Shibuya H, Pert CB.

Abstract

Small doses of the opiate antagonist naloxone selectively abolished overeating in genetically obese mice (ob/ob) and rats (fa/fa). Elevated concentrations of the naturally occurring opiate beta-endorphin were found in the pituitaries of both obese species and in the blood plasma of the obese rats. Brain levels of beta-endorphin and Leu-enkephalin were unchanged. These data suggest that excess pituitary beta-endorphin may play a role in the development of the overeating and obesity syndrome.

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beta-Endorphin is associated with overeating in genetically obese mice (ob/ob) a...
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Science. 1978 Dec 1 ;202(4371):988-91.

PubMed
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beta-Endorphin is associated with overeating in genetically obese mice (ob/ob) and rats (fa/fa).

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