A 25 year old man had a primary sclerosing cholangitis (PSC). The surgical management (cholecystostomy and external biliary drainage) failed with persistence of cholestasis and serious infection. Third surgical time impossibility induced the authors to suggest percutaneous transhepatic drainage. As well adapted and efficient with clinical and biological improvement, the drainage has been maintained. The patient was still doing well 6 months later. Therefore this radiological technique seems to be an useful palliative treatment of PSC in slowing down the evolution.