Am J Psychiatry. 1982 Sep;139(9):1170-4.

Efficacy of antipsychotic medications in behaviorally disturbed dementia patients.

Barnes R, Veith R, Okimoto J, Raskind M, Gumbrecht G.

Abstract

This study compared the therapeutic efficacy of thioridazine, loxapine, and a placebo in the treatment of behavioral disturbances in nursing home patients with dementia. Antipsychotic medications were effective for the specific behavioral problems of anxiety, excitement, emotional lability, and uncooperativeness. Subjects with the most severe symptoms at baseline assessment derived the greatest benefit from treatment. Sedation, extrapyramidal symptoms, and decreased blood pressure were common side effects among patients treated with the antipsychotic drugs. The authors conclude that antipsychotic medication has a definite but limited therapeutic role in the treatment of behavioral disturbances in nursing home patients with dementia.

PMID:: 7114310; [PubMed - indexed for MEDLINE]

LinkOut - more resources

Full Text Sources

Silverchair Information Systems

Medical

Dementia - MedlinePlus Health Information

Molecular Biology Databases

Supplemental Content

Related citations

Loxapine versus thioridazine in the treatment of organic psychosis. [J Int Med Res. 1980]
Loxapine versus thioridazine in the treatment of organic psychosis.
Versiani M, da Silva JA, Mundim FD. J Int Med Res. 1980; 8(1):22-30.
Loxapine versus chlorpromazine in paranoid schizophrenia: a double-blind study. [J Clin Psychiatry. 1984]
Loxapine versus chlorpromazine in paranoid schizophrenia: a double-blind study.
Tuason VB, Escobar JI, Garvey M, Schiele B. J Clin Psychiatry. 1984 Apr; 45(4):158-63.
Review Thioridazine for dementia. [Cochrane Database Syst Rev. 2001]
Review Thioridazine for dementia.
Kirchner V, Kelly CA, Harvey RJ. Cochrane Database Syst Rev. 2001; (3):CD000464.
Haloperidol versus thioridazine in the treatment of behavioral symptoms in senile dementia of the Alzheimer's type: preliminary findings. [J Clin Psychiatry. 1986]
Haloperidol versus thioridazine in the treatment of behavioral symptoms in senile dementia of the Alzheimer's type: preliminary findings.
Steele C, Lucas MJ, Tune L. J Clin Psychiatry. 1986 Jun; 47(6):310-2.
Review Thioridazine for dementia. [Cochrane Database Syst Rev. 2000]
Review Thioridazine for dementia.
Kirchner V, Kelly C A, Harvey RJ. Cochrane Database Syst Rev. 2000; (2):CD000464.

See reviews... See all...

Cited by 3 PubMed Central articles

Behavioural symptoms in dementia: nature and treatment. [Indian J Psychiatry. 1992]
Behavioural symptoms in dementia: nature and treatment.
Khandelwal SK, Ahuja GK, Gupta S. Indian J Psychiatry. 1992 Jan; 34(1):36-40.
Quality of life of residents with dementia in long-term care settings in the Netherlands and Belgium: design of a longitudinal comparative study in traditional nursing homes and small-scale living facilities. [BMC Geriatr. 2011]
Quality of life of residents with dementia in long-term care settings in the Netherlands and Belgium: design of a longitudinal comparative study in traditional nursing homes and small-scale living facilities.
de Rooij AH, Luijkx KG, Declercq AG, Schols JM. BMC Geriatr. 2011 May 3; 11:20. Epub 2011 May 3.
Antipsychotics for the treatment of behavioral and psychological symptoms of dementia (BPSD). [Curr Neuropharmacol. 2008]
Antipsychotics for the treatment of behavioral and psychological symptoms of dementia (BPSD).
Liperoti R, Pedone C, Corsonello A. Curr Neuropharmacol. 2008 Jun; 6(2):117-24.

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Substance
PubChem chemical substance records that cite the current articles. These references are taken from those provided on submitted PubChem chemical substance records.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.
Cited in Books
NCBI Bookshelf books that cite the current articles.

Recent activity

Clear Turn Off Turn On

Efficacy of antipsychotic medications in behaviorally disturbed dementia patient...
Efficacy of antipsychotic medications in behaviorally disturbed dementia patients.
Am J Psychiatry. 1982 Sep ;139(9):1170-4.

PubMed
Source monitoring and memory distortion.
Source monitoring and memory distortion.
Philos Trans R Soc Lond B Biol Sci. 1997 Nov 29 ;352(1362):1733-45.

PubMed
Fluoride intakes of young male adults in the United States.
Fluoride intakes of young male adults in the United States.
Am J Clin Nutr. 1980 Feb ;33(2):328-32.

PubMed
Seronegative juvenile rheumatoid arthritis and mast cell-associated gastritis.
Seronegative juvenile rheumatoid arthritis and mast cell-associated gastritis.
Arthritis Rheum. 1991 Jan ;34(1):106-9.

PubMed
Imagery ability and source monitoring: implications for eyewitness memory.
Imagery ability and source monitoring: implications for eyewitness memory.
Br J Psychol. 1993 Feb ;84 ( Pt 1):111-8.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Display Settings:

Send to:

Efficacy of antipsychotic medications in behaviorally disturbed dementia patients.

Abstract

Publication Types, MeSH Terms, Substances

Publication Types

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Medical

Molecular Biology Databases

Supplemental Content

Related citations

Cited by 3 PubMed Central articles

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information