Neurobehav Toxicol Teratol. 1982 May-Jun;4(3):365-9.

Behavioral effects of prenatal exposure to nicotine in guinea pigs.

Johns JM, Louis TM, Becker RF, Means LW.

Abstract

Nicotine (3 mg/kg SC) administered twice daily throughout pregnancy to guinea pigs resulted in offspring that were behaviorally deficient both as neonates and adults. The nicotine-treated offspring showed reduced spontaneous alternation both as neonates and adults. Also, the nicotine-treated offspring were less likely to enter a novel alley as neonates and were deficient on brightness discrimination and reversal as adults.

PMID:: 7099355; [PubMed - indexed for MEDLINE]

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Research Support, Non-U.S. Gov't

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Nicotine

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