Abstract
The induction of complete resistance to adriamycin in L1210 leukemia was accomplished after 10 transplant generations. The adriamycin-resistant subline showed cross-resistance to vincristine and bouvardin. It was sensitive to methotrexate; this was observed by a 50% increase in life span compared to the life span of untreated control animals.
MeSH terms
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Animals
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Antineoplastic Agents / pharmacology*
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Antineoplastic Agents, Phytogenic / pharmacology
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Cell Line
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Doxorubicin / pharmacology
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Drug Resistance
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Leukemia L1210 / drug therapy*
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Leukemia P388 / drug therapy
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Mice
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Mice, Inbred Strains
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Neoplasm Transplantation
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Peptides, Cyclic / pharmacology
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Vincristine / pharmacology
Substances
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Antineoplastic Agents
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Antineoplastic Agents, Phytogenic
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Peptides, Cyclic
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bouvardin
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Vincristine
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Doxorubicin