Investigations on the synthesis and properties of new derivatives of ethyl 3H-2-imino-7-methyl-4-oxopyrido [3,2-e]-1,3-thiazine-6-carboxylate and isomeric compounds

Farmaco Sci. 1982 Apr;37(4):247-58. doi: 10.1002/chin.198239266.

Abstract

Condensation of diethyl 2-chloro-6-methylpyridine-3,5-dicarboxylate (IV) with thiourea and alkyl or alkenyl N-mono- and N,N'-disubstituted thioureas gives mainly the corresponding derivatives of ethyl 3H-2-imino-7-methyl-4-oxopyrido [3,2-e]-1,3-thiazine-6-carboxylate (VI-XII). As by-products isomeric derivatives of ethyl 7-methyl-4-oxo-2-thioxo-1,2,3,4-tetrahydropyrido [2,3-d) pyrimidine-6-carboxylate (XIII-XVIII) are formed.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Anti-Inflammatory Agents / chemical synthesis
  • Anticonvulsants / chemical synthesis
  • Chemical Phenomena
  • Chemistry
  • Hexobarbital / pharmacology
  • Lethal Dose 50
  • Mice
  • Rats
  • Reserpine / antagonists & inhibitors
  • Serotonin Antagonists / chemical synthesis*
  • Sleep / drug effects
  • Thiazines / chemical synthesis*
  • Thiazines / pharmacology

Substances

  • Anti-Inflammatory Agents
  • Anticonvulsants
  • Serotonin Antagonists
  • Thiazines
  • Reserpine
  • Hexobarbital