Abstract
Condensation of diethyl 2-chloro-6-methylpyridine-3,5-dicarboxylate (IV) with thiourea and alkyl or alkenyl N-mono- and N,N'-disubstituted thioureas gives mainly the corresponding derivatives of ethyl 3H-2-imino-7-methyl-4-oxopyrido [3,2-e]-1,3-thiazine-6-carboxylate (VI-XII). As by-products isomeric derivatives of ethyl 7-methyl-4-oxo-2-thioxo-1,2,3,4-tetrahydropyrido [2,3-d) pyrimidine-6-carboxylate (XIII-XVIII) are formed.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Animals
-
Anti-Inflammatory Agents / chemical synthesis
-
Anticonvulsants / chemical synthesis
-
Chemical Phenomena
-
Chemistry
-
Hexobarbital / pharmacology
-
Lethal Dose 50
-
Mice
-
Rats
-
Reserpine / antagonists & inhibitors
-
Serotonin Antagonists / chemical synthesis*
-
Sleep / drug effects
-
Thiazines / chemical synthesis*
-
Thiazines / pharmacology
Substances
-
Anti-Inflammatory Agents
-
Anticonvulsants
-
Serotonin Antagonists
-
Thiazines
-
Reserpine
-
Hexobarbital