Identification of a specific olfactory receptor fo...[Biochem J. 1982]

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1: Biochem J. 1982 Jan 1;201(1):245-8. Links

Identification of a specific olfactory receptor for 2-isobutyl-3-methoxypyrazine.

Pelosi P, Baldaccini NE, Pisanelli AM.

2-Isobutyl-3-methoxypyrazine, a potent bell-pepper odorant, binds to cow olfactory mucosa homogenate. The receptor is saturable in the micromolar range and is competitively inhibited by other bell-pepper odourants, but not by other pyrazines of different odours. Other tissues do not bind 2-isobutyl-3-methoxypyrazine at a significant extent. We suggest that this receptor is involved in odour discrimination.

PMID: 7082286 [PubMed - indexed for MEDLINE]

PMCID: PMC1163633

Isolation and characterization of an olfactory receptor protein for odorant pyrazines.
Proc Natl Acad Sci U S A. 1985 May; 82(9):3050-4.

[Proc Natl Acad Sci U S A. 1985]
Purification and characterisation of an odorant-binding protein from cow nasal tissue.
Eur J Biochem. 1985 Jun 3; 149(2):227-31.

[Eur J Biochem. 1985]
Odorant-binding protein. Characterization of ligand binding.
J Biol Chem. 1990 Apr 15; 265(11):6118-25.

[J Biol Chem. 1990]
ReviewGrouping of odorant receptors: odour maps in the mammalian olfactory bulb.
Biochem Soc Trans. 2003 Feb; 31(Pt 1):134-6.

[Biochem Soc Trans. 2003]
ReviewOdorant receptor diversity and patterned gene expression in the mammalian olfactory epithelium.
Prog Clin Biol Res. 1994; 390:75-84.

[Prog Clin Biol Res. 1994]
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Cited by 4 PubMed Central articles

LUSH odorant-binding protein mediates chemosensory responses to alcohols in Drosophila melanogaster.
Kim MS, Repp A, Smith DP. Genetics. 1998 Oct; 150(2):711-21.

[Genetics. 1998]
Odorant-binding protein: localization to nasal glands and secretions.
Pevsner J, Sklar PB, Snyder SH. Proc Natl Acad Sci U S A. 1986 Jul; 83(13):4942-6.

[Proc Natl Acad Sci U S A. 1986]
Principles of odor coding and a neural network for odor discrimination.
Schild D. Biophys J. 1988 Dec; 54(6):1001-11.

[Biophys J. 1988]
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Structures reported by this article

Odorant-Binding Protein From Bovine Nasal Mucosa

PDB: 1OBP

Source: Bos taurus

Method: X-Ray Diffraction | Resolution: 2 Å

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Cited by 4 PubMed Central articles

Structures reported by this article

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