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Tectorial and basal membranes in experimental hypothyroidism.
The aim of the study was to trace subtle changes in the membranous labyrinth after experimental hypothyroidism that, at least in part, could explain how a reversed hearing impairment can occur, as is often clinically encountered in hypothyroid patients after thyroid substitution therapy. Adult Sprague-Dawley rats were made hypothyroid during six weeks by the use of methimazole in their drinking water. Their inner ears were investigated morphologically at the end of this period. The tectorial membrane is the first structure of the inner ear to show morphologic changes in hypothyroidism. Changes in the normal position and structure constantly were found. A thickening of the basilar membrane was indicated in many, but not all, specimens and in some control animals and may be coincidental. The initial morphologic changes are likely to be reversible after substitution therapy.
PMID: 7073592 [PubMed - indexed for MEDLINE]
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Patient Drug Information
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Thyroid (Armour® Thyroid)
Thyroid is a hormone produced by the body. When taken correctly, thyroid is used to treat the symptoms of hypothyroidism (a condition where the thyroid gland does not produce enough thyroid hormone). Symptoms of hypothyr...
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Methimazole (Tapazole® )
Methimazole is used to treat hyperthyroidism, a condition that occurs when the thyroid gland produces too much thyroid hormone. It is also taken before thyroid surgery or radioactive iodine therapy.