Antibody to influenza virus matrix protein detects a common antigen on the surface of cells infected with type A influenza viruses

J Exp Med. 1977 Sep 1;146(3):690-7. doi: 10.1084/jem.146.3.690.

Abstract

Antisera to the type-specific internal influenza virus matrix (M) protein of a type A influenza virus were produced in goats. In the presence of complement, anti-M serum was cytotoxic for target cells which were infected with a variety of serologically distinct type A influenza viruses, but did not react with type B influenza virus-infected cells. Absorption experiments indicated that anti-M serum detected a common antigen(s) on the surface of type A-infected cells. This serological cross-reactivity parallels the cross-reactivity observed for the cytotoxic T-cell response to type A viruses.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Antibodies, Viral*
  • Antigens, Viral / analysis*
  • Cell Line
  • Cell Membrane / immunology*
  • Cytotoxicity Tests, Immunologic
  • Epitopes
  • Influenza A virus / immunology*
  • Viral Proteins / immunology*

Substances

  • Antibodies, Viral
  • Antigens, Viral
  • Epitopes
  • Viral Proteins