Format

Send to

Choose Destination
See comment in PubMed Commons below
Prostaglandins. 1978 Aug;16(2):239-44.

Chemotactic activity of thromboxane B2, prostaglandins and their metabolites for polymorphonuclear leucocytes.

Abstract

(1) The chemotactic activities of thromboxane B2 (TxB2), PGE2, PGF2alpha, the 15-oxo, 15-oxo-13,14-dihydro and 13,14-dihydro metabolites of PGE2, PGF2alpha, and a metabolite of TxB2 for polymorphonuclear leucocytes (PMN) have been investigated. (2) Thromboxane B2 increased the directional migration of rat peritoneal PMN at a concentration of 2.0 micrograms/ml and of human peripheral neutrophils at a concentration of 0.5 microgram/ml. (3) Neither PGE2, PGF2alpha nor their metabolites showed chemotactic activity for rat peritoneal PMN. (4) PGF2alpha and 15-oxo-13,14-dihydro-thromboxane B2 showed no chemotactic activity for human peripheral PMN. (5) The possible role of thromboxane B2 in inflammation is discussed.

PMID:
704931
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Loading ...
    Write to the Help Desk