Arch Dis Child. 1982 Jan;57(1):18-21.

Screening for cystic fibrosis by died blood spot trypsin assay.

Heeley AF, Heeley ME, King DN, Kuzemko JA, Walsh MP.

Abstract

Immunoreactive trypsin was measured in dried blood specimens from 14,000 infants. A second test was performed in 0 . 2% of the population in whom blood trypsin levels were greater than 80 ng/ml. Five infants with cystic fibrosis were then detected, with only one case of persistent hypertrypsinaemia in whom this diagnosis could not be established. No false-negative test results have yet been identified. Seventeen infants with cystic fibrosis were tested inthe first 2 weeks of life, only one of whom had a blood trypsin concentration less than 80 ng/ml.

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PMCID:: PMC2863277

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Cited by 14 PubMed Central articles

With commentary. [Arch Dis Child. 1982]
With commentary.
Phelan PD. Arch Dis Child. 1982 Oct; 57(10):779-80.
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