A method was devised for surgical removal of the pyloric antrum in 3-week-old rats. Contrary to published experiences with older rats, it was found that ligation of right and left gastroepiploic arteries was not necessary in young animals. Erythrocytes and fluids were routinely administered postoperatively, and recovered animals were denied access to water and food for 2 and 3 days, respectively. When the rats were fasted overnight prior to surgery, the recovery rate was 87% (27 of 31 attempted). Surgical sites were intact and showed minimal adhesions 2 months later. When overnight fasting was omitted, only 57% survived (8 of 14 attempted), because extensive manipulations were necessary to remove gastric contents, and this often produced shock.