Alcohol Clin Exp Res. 1981 Fall;5(4):528-30.

The disulfiram (Antabuse)-Alcohol reaction in male alcoholics: its efficient management by 4-methylpyrazole.

Lindros KO, Stowell A, Pikkarainen P, Salaspuro M.

Abstract

4-methylpyrazole (4-MP), an inhibitor of alcohol dehydrogenase, rapidly abolished the accumulation of acetaldehyde following alcohol ingestion both in volunteers pretreated with the Antabuse analog calcium carbimide and in an antabuse-treated alcoholic. 4-MP also attenuated other typical symptoms, including facial flushing and tachycardia, thus suggesting its usefulness in the acute treatment of severe disulfiram-alcohol reactions.

PMID:: 7030108; [PubMed - indexed for MEDLINE]

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A placebo-controlled double-blind comparative clinical study of the disulfiram- and calcium carbimide-acetaldehyde mediated ethanol reactions in social drinkers. [Alcohol Clin Exp Res. 1983]
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Cited by 1 PubMed Central article

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The disulfiram (Antabuse)-Alcohol reaction in male alcoholics: its efficient man...
The disulfiram (Antabuse)-Alcohol reaction in male alcoholics: its efficient management by 4-methylpyrazole.
Alcohol Clin Exp Res. 1981 Fall ;5(4):528-30.

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