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Proteolytic activity of blowfly larvae secretions in experimental burns.
Secretions of larvae of the blowfly Calliphora erythrocephala digested experimental rat skin burn eschar in vivo and in vitro when applied topically in a vanishing cream base. Debridement was characterized by de-epithelialization and digestion of dermal collagen to a subfollicular level over a 3-day period. Analytic investigation of the secretions demonstrated the presence of enzymes with activities characteristic of trypsin, leucine aminopeptidase, and carboxypeptidases A and B. These were partially characterized. There was no evidence of chymotrypsin, elastase, or collagenase. Preparation of a suitable therapeutic form could result in a preparation useful for enzymatic debridement.
PMID: 7029766 [PubMed - indexed for MEDLINE]
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Cited by 3 PubMed Central articles
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ReviewNeuroprotection in glaucoma using calpain-1 inhibitors: regional differences in calpain-1 activity in the trabecular meshwork, optic nerve and implications for therapeutics.
Govindarajan B, Laird J, Sherman R, Salomon RG, Bhattacharya SK.
CNS Neurol Disord Drug Targets. 2008 Jun; 7(3):295-304.
[CNS Neurol Disord Drug Targets. 2008]
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Maggot Therapy: The Science and Implication for CAM Part I-History and Bacterial Resistance.
Nigam Y, Bexfield A, Thomas S, Ratcliffe NA.
Evid Based Complement Alternat Med. 2006 Jun; 3(2):223-7. Epub 2006 May 5.
[Evid Based Complement Alternat Med. 2006]
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Maggot therapy revisited.
Bunkis J, Gherini S, Walton RL.
West J Med. 1985 Apr; 142(4):554-6.
[West J Med. 1985]