Drug Alcohol Depend. 1980 Oct;6(4):201-8.

Efficacy of clonidine in opiate withdrawal: a study of thirty patients.

Gold MS, Pottash AL, Sweeney DR, Kleber HD.

Abstract

In a placebo-controlled, double-blind crossover trial, clonidine caused a marked and significant reduction of objective signs and subjective symptoms of opiate withdrawal in thirty hospitalized opiate addicts. In an open trial of clonidine in opiate withdrawal, clonidine was found to suppress opiate withdrawal signs and symptoms, allowing all of the patients to detoxify successfully from chronic opiate addiction. Clonidine was demonstrated to reverse and suppress the signs, symptoms, and effects associated with opiate withdrawal. These data support a release from chronic opiate-induced noradrenergic inhibition producing noradrenergic hyperactivity as the pathophysiological substrate for opiate withdrawal. Clonidine replaces opiate-mediated inhibition with alpha-2 mediated inhibition of noradrenergic nuclei.

PMID:: 7023893; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances

Publication Types

Clinical Trial

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Elsevier Science

Molecular Biology Databases

CLONIDINE - HSDB

Supplemental Content

Related citations

Clonidine in opiate withdrawal: review and appraisal of clinical findings. [Pharmacotherapy. 1981]
Clonidine in opiate withdrawal: review and appraisal of clinical findings.
Washton AM, Resnick RB. Pharmacotherapy. 1981 Sep-Oct; 1(2):140-6.
Double-blind randomized controlled trial of baclofen vs. clonidine in the treatment of opiates withdrawal. [J Clin Pharm Ther. 2000]
Double-blind randomized controlled trial of baclofen vs. clonidine in the treatment of opiates withdrawal.
Akhondzadeh S, Ahmadi-Abhari SA, Assadi SM, Shabestari OL, Kashani AR, Farzanehgan ZM. J Clin Pharm Ther. 2000 Oct; 25(5):347-53.
Passionflower in the treatment of opiates withdrawal: a double-blind randomized controlled trial. [J Clin Pharm Ther. 2001]
Passionflower in the treatment of opiates withdrawal: a double-blind randomized controlled trial.
Akhondzadeh S, Kashani L, Mobaseri M, Hosseini SH, Nikzad S, Khani M. J Clin Pharm Ther. 2001 Oct; 26(5):369-73.
Review Clonidine and the treatment of the opiate withdrawal syndrome. [Drug Alcohol Depend. 1988]
Review Clonidine and the treatment of the opiate withdrawal syndrome.
Gossop M. Drug Alcohol Depend. 1988 Jul; 21(3):253-9.
Review Clonidine treatment of the opiate withdrawal syndrome. A review of clinical trials of a theory. [Acta Psychiatr Scand Suppl. 1986]
Review Clonidine treatment of the opiate withdrawal syndrome. A review of clinical trials of a theory.
Agren H. Acta Psychiatr Scand Suppl. 1986; 327:91-113.

See reviews... See all...

Cited by 1 PubMed Central article

Oral clonidine pretreatment prior to venous cannulation. [Anesth Prog. 2006]
Oral clonidine pretreatment prior to venous cannulation.
Hall DL, Rezvan E, Tatakis DN, Walters JD. Anesth Prog. 2006 Summer; 53(2):34-42.

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Efficacy of clonidine in opiate withdrawal: a study of thirty patients.
Efficacy of clonidine in opiate withdrawal: a study of thirty patients.
Drug Alcohol Depend. 1980 Oct ;6(4):201-8.

PubMed
Guideline for isolation precautions in hospitals. Part II. Recommendations for i...
Guideline for isolation precautions in hospitals. Part II. Recommendations for isolation precautions in hospitals. Hospital Infection Control Practices Advisory Committee.
Am J Infect Control. 1996 Feb ;24(1):32-52.

PubMed
Sgs1: a eukaryotic homolog of E. coli RecQ that interacts with topoisomerase II ...
Sgs1: a eukaryotic homolog of E. coli RecQ that interacts with topoisomerase II in vivo and is required for faithful chromosome segregation.
Cell. 1995 Apr 21 ;81(2):253-60.

PubMed
Silver products for medical indications: risk-benefit assessment.
Silver products for medical indications: risk-benefit assessment.
J Toxicol Clin Toxicol. 1996 ;34(1):119-26.

PubMed
Filariasis of the breast.
Filariasis of the breast.
Arch Pathol Lab Med. 1987 Aug ;111(8):757-9.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Display Settings:

Send to: