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1: Br J Psychiatry. 1981 Jan;138:46-50.Links

Physostigmine and arecoline: effects of intravenous infusions in Alzheimer presenile dementia.

Christie JE, Shering A, Ferguson J, Glen AI.

Physostigmine (0.25 mg-1 mg), arecoline (2 and 4 mg) and saline were administered intravenously over 30 minutes in a randomized double blind design to 11 patients with a clinical diagnosis of Alzheimer presenile dementia. Significant improvement was seen on a picture recognition test with physostigmine 0.375 mg and arecholine 4 mg. A trend towards improvement was also seen with physostigmine 0.25 mg and 0.75 mg, and arecholine 2 mg. For the majority of the patients improvement was only slight but in two patients it was clear cut and consistent.

PMID: 7023592 [PubMed - indexed for MEDLINE]