Metabolic activation of 1-methyl-3-amino-5H-pyrido[4,3-b]indole and several structurally related mutagens

Biochemistry. 1981 Jan 20;20(2):298-305. doi: 10.1021/bi00505a011.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Biotransformation
  • Carbolines / metabolism
  • Carbolines / pharmacology*
  • Chemical Phenomena
  • Chemistry
  • DNA
  • Indoles / pharmacology*
  • Methionine
  • Methods
  • Methylcholanthrene / pharmacology
  • Microsomes, Liver / drug effects
  • Microsomes, Liver / metabolism*
  • Mutagenicity Tests
  • Mutagens*
  • Rats
  • Salmonella typhimurium / drug effects
  • Structure-Activity Relationship

Substances

  • Carbolines
  • Indoles
  • Mutagens
  • Methylcholanthrene
  • 3-amino-1-methyl-5H-pyrido(4,3-b)indole
  • DNA
  • Methionine