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Cancer Treat Rep. 1980 Apr-May;64(4-5):689-92.

Results of the Royal Marsden Hospital second soft tissue sarcoma schedule (STS II) chemotherapy regimen in the management of advanced sarcoma.


Forty-eight patients with advanced soft tissue sarcoma were treated with a five-drug combination regimen consisting of vincristine, actinomycin D, and cyclophosphamide (Day 1) followed by doxorubicin and an infusion of methotrexate (Day 22). Thirty-seven of the 48 patients were fully evaluable. Of the 37 evaluable patients, two achieved a complete remission and three achieved a partial remission, with an overall response rate of 13.5%. These results compare unfavorably with previously reported series from this and other centers, and the regimen has now been superseded.

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