Cell. 1978 Sep;15(1):279-81.

Recessive male-determining genes.

Abstract

The autosomal dominant gene polled (P) causes hornlessness in goats. Chromosomal females (XX) that are P/P homozygotes develop testes or ovotestes. Thus with respect to its testis-determining properties, P or a closely linked gene acts as an autosomal recessive. Polled intersex goats are H-Y+. This finding is consistent with the view that there may be a cluster of testis-determining H-Y genes on the Y chromosome, and that translocation of a subcritical portion of these genes may generate a recessive mode of sex determination.

PMID:: 699047; [PubMed - indexed for MEDLINE]

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H-Y Antigen

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Immunogenetics of sex determination of the polled goat. [Cytogenet Cell Genet. 1980]
Immunogenetics of sex determination of the polled goat.
Shalev A, Short RV, Hamerton JL. Cytogenet Cell Genet. 1980; 28(3):195-202.
Recessive sex-determining genes in human XX male syndrome. [Cell. 1978]
Recessive sex-determining genes in human XX male syndrome.
de la Chapelle A, Koo GC, Wachtel SS. Cell. 1978 Nov; 15(3):837-42.
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Fraccaro M, Tiepolo L, Zuffardi O, Chiumello G, Di Natale B, Gargantini L, Wolf U. Hum Genet. 1979 Apr 17; 48(1):45-52.
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Review The Y-linked testis determining gene and H-Y plasma membrane antigen gene: are they one and the same?
Ohno S. Endocr Rev. 1985 Summer; 6(3):421-31.
Review Primary sex determination: genetics and biochemistry. [Mol Cell Biochem. 1980]
Review Primary sex determination: genetics and biochemistry.
Hall JL, Wachtel SS. Mol Cell Biochem. 1980 Dec 10; 33(1-2):49-66.

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Cited by 4 PubMed Central articles

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A regulatory cascade hypothesis for mammalian sex determination: SRY represses a negative regulator of male development. [Proc Natl Acad Sci U S A. 1993]
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McElreavey K, Vilain E, Abbas N, Herskowitz I, Fellous M. Proc Natl Acad Sci U S A. 1993 Apr 15; 90(8):3368-72.
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Female phenotype and multiple abnormalities in sibs with a Y chromosome and partial X chromosome duplication: H--Y antigen and Xg blood group findings.
Bernstein R, Jenkins T, Dawson B, Wagner J, Dewald G, Koo GC, Wachtel SS. J Med Genet. 1980 Aug; 17(4):291-300.

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Recessive male-determining genes.

Abstract

MeSH Terms, Substances

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Substances

LinkOut - more resources

Full Text Sources

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Cited by 4 PubMed Central articles

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