Biochim Biophys Acta. 1978 Sep 28;530(3):451-60.

Enzymatic sulphation of bile salts in human liver.

Abstract

An enzyme catalyzing the transfer of the sulphate group from 3' -phosphoadenosine-5' -phosphosulphate to lithocholate and glycolithocholate is identified in the cytosol of human liver. The rate of sulphation was greatest with unconjugates lithocolate. Km values for lithocholate and glycolithocholate were 2 . 10(-6) and 3.3 . 10(-6) M, respectively. No enzyme activity was found in human kidney cytosol. A simple method for quantitative assay of the enzyme in percutaneous liver biopsy specimens is described.

PMID:: 698243; [PubMed - indexed for MEDLINE]

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