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Enzyme. 1982;28(1):76-81.

Magnesium and magnesium adenosine triphosphate activation of human propionyl CoA carboxylase and beta-methylcrotonyl CoA carboxylase.

Abstract

Free magnesium and MgATP2- are required for activation of the mitochondrial enzymes pyruvate carboxylase, propionyl CoA carboxylase and beta-methylcrotonyl CoA carboxylase. Previous studies have demonstrated that free Mg2+ interacts with either a Mg2+- binding site or one of the two MgATP2- sites that are required for the allosteric activation of pyruvate carboxylase. We have shown that similar Mg2+ and MgATP2- interactions occur to activate propionyl CoA carboxylase and beta-methylcrotonyl CoA carboxylase. Thus, Mg2+ and MgATP2- activation, because it is common to structurally similar carboxylases, may constitute a general mode of carboxylase activation.

PMID:
6981505
[PubMed - indexed for MEDLINE]
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