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Carbon catabolite regulation of cephalosporin production in Streptomyces clavuligerus.
Cephalosporin production by Streptomyces clavuligerus is regulated by some type of carbon catabolite control. Increasing concentrations of preferred carbon sources, such as glycerol and maltose, decreased production of the antibiotics. Poorer carbon sources, such as alpha-ketoglutarate and succinate, led to high specific production of cephalosporins and shifted the dynamics of fermentation to a greater degree of association with growth. The results support the concept that the phase in which a product is made by a microorganism is not a function of the particular molecule produced, but rather of the nutritional environment presented to the organism.
PMID: 697343 [PubMed - indexed for MEDLINE]
PMCID: PMC352426
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Cited by 10 PubMed Central articles
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Five additional genes are involved in clavulanic acid biosynthesis in Streptomyces clavuligerus.
Jensen SE, Paradkar AS, Mosher RH, Anders C, Beatty PH, Brumlik MJ, Griffin A, Barton B.
Antimicrob Agents Chemother. 2004 Jan; 48(1):192-202.
[Antimicrob Agents Chemother. 2004]
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Investigation of the Streptomyces clavuligerus cephamycin C gene cluster and its regulation by the CcaR protein.
Alexander DC, Jensen SE.
J Bacteriol. 1998 Aug; 180(16):4068-79.
[J Bacteriol. 1998]
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Molecular analysis of a beta-lactam resistance gene encoded within the cephamycin gene cluster of Streptomyces clavuligerus.
Paradkar AS, Aidoo KA, Wong A, Jensen SE.
J Bacteriol. 1996 Nov; 178(21):6266-74.
[J Bacteriol. 1996]
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